MilliporeSigma™ Mouse anti-PTHrP (1-34), Clone: 23-57-137-1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN793

Catalog No. MABN793MI

Description

Specifically detects PTHrP (1-34) clone: 23-57-137-1 in Human samples, and it is validated for Neutralization, Western Blotting

Parathyroid hormone-related protein (UniProt P12272), also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid protein, which is then cleaved into PTHrP(1-34), PTHrP(1-36), PTHrP(38-94), and Osteostatin (also known as PTHrP (107-139)). Malignancy-associated hypercalcemia is caused by excessive production of parathyroid hormone-related protein (PTHrP) by the tumor. Neutralizing PTHrP(1-34) by antibody injection is shown to reduce serum calcium levels in hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors, leading to their prolonged survival. (PMID 8352067, 11668474, 15517871, 16036863, 19342773)

Specifications

• Antigen: PTHrP (1-34)
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
• Gene Symbols: PTHLH; PTHRP
• Immunogen: Bovine thyroglobulin-conjugated linear peptide corresponding to human PTHrP(1-34).
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_002811
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Isotype: IgG1 κ

• Applications: Neutralization, Western Blot
• Clone: 23-57-137-1
• Gene Accession No.: P12272
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only