PTK2B, Mouse, Clone: 5E2D5, Abnova™

Catalog No.	Quantity
89-108-546	100 μL

Catalog No. 89-108-546 Supplier Abnova Corporation Supplier No. MAB10359

Description

Mouse monoclonal antibody raised against partial recombinant PTK2B.

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: PTK2B
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: 5E2D5
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant PTK2B.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: PTK2B
• Gene Alias: CADTK/CAKB/FADK2/FAK2/FRNK/PKB/PTK/PYK2/RAFTK
• Gene Symbols: PTK2B
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 815-997 of human PTK2B.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2185
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a