PTPN11, Mouse, Clone: SIT-01, Abnova™

Catalog No.	Quantity
89-112-184	100 μg

Catalog No. 89-112-184 Supplier Abnova Corporation Supplier No. MAB5240

Description

Mouse monoclonal antibody raised against partial recombinant PTPN11.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq

Specifications

• Antigen: PTPN11
• Applications: Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: SIT-01
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant PTPN11.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene: PTPN11
• Gene Alias: BPTP3/CFC/MGC14433/NS1/PTP-1D/PTP2C/SH-PTP2/SH-PTP3/SHP2
• Gene Symbols: PTPN11
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to intracellular region of human PTPN11.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5781
• Test Specificity: human SHP2-interacting transmembrane adapter protein (SIT). Weaker reactivity was observed with mouse homolog.
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1