PTPN6, Mouse, Clone: PTY11, Abnova™

Mouse monoclonal antibody raised against full-length recombinant PTPN6.

Supplier:  Abnova Corporation MAB6401

Catalog No. 89-112-856

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

Specifications

• Antigen: PTPN6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: PTPN6
• Gene Symbols: PTPN6
• Immunogen: Recombinant protein corresponding to full length human PTPN6.
• Regulatory Status: RUO
• Gene ID (Entrez): 5777
• Target Species: Human
• Form: Lyophilized

• Applications: ELISA, Immunocytochemistry, Western Blot
• Clone: PTY11
• Description: Mouse monoclonal antibody raised against full length recombinant PTPN6.
• Formulation: Lyophilized from 10mM PBS, pH 7.2
• Gene Alias: HCP/HCPH/HPTP1C/PTP-1C/SH-PTP1/SHP-1/SHP-1L/SHP1
• Host Species: Mouse
• Quantity: 500 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes single 67 KDa PTPN6 in human cells that express the enzyme and the SH2(C) domain.
• Content And Storage: Store at -20°C.
  Aliquot after reconstitution to avoid repeated freezing and thawing.
• Isotype: IgG1 κ