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PTPRC, Mouse, Clone: T29/33, Abnova™

Catalog No. 89111723 Shop All Abnova Corporation Products
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200 μg
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Catalog No. Quantity
89-111-723 200 μg
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Catalog No. 89-111-723 Supplier Abnova Corporation Supplier No. MAB4194

Description

Mouse monoclonal antibody raised against PTPRC.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

Specifications

Antigen PTPRC
Applications Flow Cytometry
Classification Monoclonal
Clone T29/33
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against PTPRC.
Dilution Flow Cytometry (1ug stain 1.0x106 cells) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, 2mM EDTA, pH 7.2 (1% BSA, 0.09% sodium azide)
Gene PTPRC
Gene Alias B220/CD45/CD45R/GP180/LCA/LY5/T200
Gene Symbols PTPRC
Host Species Mouse
Immunogen Human PTPRC.
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5788
Test Specificity Anti-human CD45 (LCA) recognizes the common leukocyte antigens (190-220 KDa), which are members of the T200 glycoprotein complex. The CD45 antigen is a protein tyrosine phosphatase. The CD45 antigen is present on all human leukocytes and progenitors in bone marrow. This antibody binds to all human hematopoietic cells, but not to non-hematopoietic cells. Anti-CD45 (T29/33) is not cytotoxic in the presence of complement.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2b
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