PTPRC, Mouse, PerCP, Clone: MEM-28, Abnova™

Catalog No.	Quantity
89-111-916	100 Reactions

Catalog No. 89-111-916 Supplier Abnova Corporation Supplier No. MAB4590

Description

Mouse monoclonal antibody raised against native PTPRC.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

Specifications

• Antigen: PTPRC
• Applications: Flow Cytometry, Immunofluorescence
• Classification: Monoclonal
• Clone: MEM-28
• Conjugate: PerCP
• Description: Mouse monoclonal antibody raised against native PTPRC.
• Dilution: Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene: PTPRC
• Gene Alias: B220/CD45/CD45R/GP180/LCA/LY5/T200
• Gene Symbols: PTPRC
• Host Species: Mouse
• Immunogen: Native purified PTPRC from human thymocytes and T lymphocytes.
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5788
• Test Specificity: This antibody reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 KDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1