RAF1, Mouse, Clone: M208, Abnova™

Catalog No.	Quantity
89-113-035	100 μL

Catalog No. 89-113-035 Supplier Abnova Corporation Supplier No. MAB6771

Description

Mouse monoclonal antibody raised against synthetic peptide of RAF1.

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq

Specifications

• Antigen: RAF1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: M208
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against synthetic peptide of RAF1.
• Dilution: ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide)
• Gene: RAF1
• Gene Alias: CRAF/NS5/Raf-1/c-Raf
• Gene Symbols: RAF1
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to N-terminus of human RAF1.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5894
• Test Specificity: This C-Raf sequence has high homology to rat and mouse C-Raf.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1