RAG2, Mouse, Clone: 4D5, Abnova™

Catalog No.	Quantity
89-108-498	100 μL

Catalog No. 89-108-498 Supplier Abnova Corporation Supplier No. MAB10311

Description

Mouse monoclonal antibody raised against partial recombinant RAG2.

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq

Specifications

• Antigen: RAG2
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 4D5
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant RAG2.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: RAG2
• Gene Alias: RAG-2
• Gene Symbols: RAG2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 350-527 of human RAG2.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5897
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1