Rb, Mouse, Clone: 3C11, Abnova™

Catalog No.	Quantity
89-107-814	100 μg

Catalog No. 89-107-814 Supplier Abnova Corporation Supplier No. MAB0003

Description

Mouse monoclonal antibody raised against synthetic phosphopeptide of Rb.

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq

Specifications

• Antigen: Rb
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 3C11
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against synthetic phosphopeptide of Rb.
• Dilution: Western Blot (1-2 ug/mL) Immunoprecipitation (2-4 ug/mL) ELISA (5-10 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 10mM phosphate buffer, 150mM NaCl, pH 7.5 (50% glycerol)
• Gene: RB1
• Gene Accession No.: NM_000321
• Gene Alias: OSRC/RB/p105-Rb/pRb/pp110
• Gene Symbols: RB1
• Host Species: Mouse
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S612 of human Rb.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5925
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a