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RELA, Mouse, Clone: 27F9.G4, Abnova™

Catalog No. 89108460 Shop All Abnova Corporation Products
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89-108-460 100 μg
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Catalog No. 89-108-460 Supplier Abnova Corporation Supplier No. MAB10259
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Description

Mouse monoclonal antibody raised against synthetic peptide of RELA.

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM

Specifications

Antigen RELA
Applications Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Classification Monoclonal
Clone 27F9.G4
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic peptide of RELA.
Dilution Western Blot (1:1000) IHC (1:200-1:600) IF (1:5000) The optimal working dilution should be determined by the end user.
Formulation In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide)
Gene RELA
Gene Alias MGC131774/NFKB3/p65
Gene Symbols RELA
Host Species Mouse
Immunogen A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RELA.
Purification Method Protein A purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5970
Test Specificity This product showed a single band by IEP (immunoelectrophoresis) when tested with anti-mouse antibody. Reactivity was confirmed by ELISA against peptide conjugated carrier protein and by Western blot against HeLa whole cell lysate.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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