Perlecan Mouse anti-Human, Unlabeled, Clone: 5D7-2E4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565781

Catalog No. BDB565781

Description

The 5D7-2E4 monoclonal antibody specifically recognizes the protein core of Perlecan (PRCAN), which has a calculated molecular mass of ~460 kDa. Smaller molecular mass species of Perlecan have also been described. Perlecan is also known as Heparan sulfate proteoglycan 2 (HSPG2), or Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG). Perlecan is a large multidomain proteoglycan that is produced by epithelial and endothelial cells. It is a major component of the vascular extracellular matrix and helps sustain endothelial barrier function. Perlecan inhibits smooth muscle cell proliferation and serves as an attachment substrate for cells. It plays essential roles in normal cartilage, heart and vascular development, as well as, in the response to vascular injury.

Specifications

• Antigen: Perlecan
• Clone: 5D7-2E4
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Murine
• Isotype: IgG₁, κ
• Quantity: 50μg
• Storage Requirements: Store undiluted at 4°C
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.5mg/mL
• Description: PRCAN; HSPG2; HSPG; Endorepellin; LG3; PLC; SJA; SJS; SJS1
• Format: Affinity Purified
• Immunogen: Purified full-length Human Perlecan
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human