RPSA, Mouse, Clone: 69j0, Abnova™

Catalog No.	Quantity
89-113-629	100 μL

Catalog No. 89-113-629 Supplier Abnova Corporation Supplier No. MAB8870

Description

Mouse monoclonal antibody raised against full-length recombinant RPSA.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as nonintegrin laminin-binding proteins. This gene encodes a high-affinity, nonintegrin family, laminin receptor 1. This receptor has been variously called 67kDa laminin receptor, 37kDa laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Specifications

• Antigen: RPSA
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 69j0
• Concentration: 1 ug/uL
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against full length recombinant RPSA.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In citrate-Tris-HCl, pH7.0 (0.02% Proclin 300)
• Gene: RPSA
• Gene Alias: 37LRP/67LR/LAMBR/LAMR1/LRP/p40
• Gene Symbols: RPSA
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to full length of human RPSA.
• Purification Method: Affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3921
• Test Specificity: This antibody recognizes LR expression in Hela whole cell lysate.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1