MilliporeSigma™ Mouse anti-S100A9, Clone: 6B4,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABF854

Catalog No. MABF854MI

Description

Specifically detects S100A9 clone: 6B4 in Human samples, and it is validated for ELISA, Western Blotting

Protein S100-A9 (UniProt P06702; also known as Calgranulin-B, Calprotectin L1H subunit, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, S100 calcium-binding protein A9, S100A9) is encoded by the S100A9 (also known as 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MRP14) gene (Gene ID 6280) in human. S100A9 is one of the 21 members of the S100 family of proteins. S100A8 (calgranulin-A), S100A9 (calgranulin-B) and the heterdimer S100A8/S100A9 (calprotectin) exert their immunological and inflammatory action via binding to TLR-4, RAGE and some other putative receptors. S100A8, calprotectin, and S100A9 are chemoattractants for neutrophils, and S100A9 is known to induce the expression and activation of beta2-integrins. S100A9 is also shown to stimulate neutrophil degranulation and phagocytosis, while both S100A8 and S100A9 can induce the secretion of inflammatory cytokines from human monocytes. In addition, S100A9 is shown to potentiate both fMLP- and GM-CSF-stimulated IL-8 production from neutrophils, although S100A9 on its own cannot induce neutrophil cytokine production in the absence of fMLP and GM-CSF.

Specifications

• Antigen: S100A9
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing PBS without preservatives.
• Gene Symbols: S100A9; CAGB; CFAG; MRP14
• Immunogen: Recombinant protein corresponding to human S100A9.
• Quantity: 100 μg
• Research Discipline: Inflammation and Immunology
• Gene ID (Entrez): NP_002956
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot
• Clone: 6B4
• Gene Accession No.: P06702
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only