SIRPA, Mouse, Clone: 1D10, Abnova™

Catalog No.	Quantity
89-107-630	200 μL

Catalog No. 89-107-630 Supplier Abnova Corporation Supplier No. H00140885M01A

Description

Mouse monoclonal antibody raised against a full-length recombinant SIRPA.

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq

Sequence: VAGEEELQVIQPDKSVSVAAGESAILHCTVTSLIPVGPIQWFRGAGPARELIYNQKEGHFPRVTTVSESTKRENMDFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREITQVQSLDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK

Specifications

• Antigen: SIRPA
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 1D10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a full-length recombinant SIRPA.
• Formulation: ascites with no preservative
• Gene: SIRPA
• Gene Accession No.: BC026692
• Gene Alias: BIT/CD172A/MFR/MYD-1/P84/PTPNS1/SHPS-1/SHPS1/SIRP/SIRP-ALPHA-1/SIRPalpha/SIRPalpha2
• Gene Symbols: SIRPA
• Host Species: Mouse
• Immunogen: SIRPA (AAH26692,28 a.a. ∽ 507 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 140885
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Ascites
• Isotype: IgG2a κ