SKP2, Mouse, Clone: 1, Abnova™

Catalog No.	Quantity
89-113-934	100 μg

Catalog No. 89-113-934 Supplier Abnova Corporation Supplier No. MAB9976

Description

Mouse monoclonal antibody raised against partial recombinant SKP2.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. [provided by RefSeq]

Specifications

• Antigen: SKP2
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 1
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant SKP2.
• Dilution: Western blot (1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In Citrate-Tris-HCl buffer, pH 7.0 (0.02% Proclin 300)
• Gene: SKP2
• Gene Alias: FBL1/FBXL1/FLB1/MGC1366
• Gene Symbols: SKP2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 21-270 of human SKP2.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6502
• Test Specificity: It can expression in HEK293 whole cell lysate.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1