SORL1, Mouse, Clone: 7D7B11, Abnova™

Catalog No.	Quantity
89-108-554	100 μL

Catalog No. 89-108-554 Supplier Abnova Corporation Supplier No. MAB10367

Description

Mouse monoclonal antibody raised against partial recombinant SORL1.

This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. [provided by RefSeq

Specifications

• Antigen: SORL1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 7D7B11
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant SORL1.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: SORL1
• Gene Alias: C11orf32/FLJ21930/FLJ39258/LR11/LRP9/SORLA/SorLA-1/gp250
• Gene Symbols: SORL1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 2159-2214 of human SORL1.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6653
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1