MilliporeSigma™ Mouse anti-SOX9, Clone: 10E4.1,

Catalog No.	Quantity
MABC277	100 μg

Catalog No. MABC277 Supplier MilliporeSigma™ Supplier No. MABC277

Description

Mouse Monoclonal Antibody

Specifically detects SOX9 clone: 10E4.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation

Transcription factor SOX-9 (UniProt P48436; also known as Sex-determining region Y-box 9 protein, SRY-related HMG-box gene 9) is encoded by the SOX9 (also known as CMD1, CMPD1, SRA1) gene (Gene ID 6662) in human. Sox family of genes are related to the mammalian sex determining gene SRY. These genes contain sequences encoding for the HMG-box domains that mediate sequence-specific DNA binding. SOX genes encode transcriptional regulators involved in cell fate decision during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at at least 40 genomic loci and at least 30 Sox genes have been identified. SOX-9 is a key regulator of developmental processes, including male sex determination, chondrogenesis, neurogenesis, and neural crest development. SOX-9 up-regulation is reported in cancers of various origins, including breast, colon, prostate, and lung, where its expression correlates with malignancy and patient survival. Cellular SOX9 mRNA is shown to be targeted and negatively regulated by miR-32, and the cellular miR-32 level is reported to be significantly lower in non-small cell lung cancer (NSCLC) compared with noncancerous lung tissues.

Specifications

• Antigen: SOX9
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Monoclonal
• Clone: 10E4.1
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P48436
• Gene Symbols: SOX9; CMD1; CMPD1; SRA1
• Host Species: Mouse
• Immunogen: GST-tagged recombinant protein corresponding to a sequence from the N-terminal region of human SOX9.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Apoptosis, Cancer
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_000337
• Target Species: Human, Mouse, Rat
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only