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MilliporeSigma™ Mouse anti-Src, Clone: GD11, Alexa Fluor 488,

Catalog No. 05184AF488 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 488
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Catalog No. Quantity Conjugate
05-184-AF488 100 μL Alexa Fluor 488
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Catalog No. 05-184-AF488 Supplier MilliporeSigma™ Supplier No. 05184AF488
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Description

Mouse Monoclonal Antibody

Specifically detects Src clone: GD11 in Avian, Human, Mink, Mouse, Rat samples, and it is validated for Immunocytochemistry

Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2; UniProt P00526; also known as p60-Src, pp60v-src, v-Src) is encoded by the V-SRC gene (Gene ID 1491925) of Rous sarcoma virus strain Prague C (RSV-PrC). Rous sarcoma virus (RSV) V-SRC gene is the first retroviral oncogene discovered. V-SRC encodes the v-Src tyrosine kinase that transforms infected host cells into uncontrolled mitosis, providing abundant cells for fresh infection. The non-oncogenic chicken c-Src (cellular Src) gene structurally related to v-Src was discovered later in 1979 by J. Michael Bishop and Harold E. Varmus. It is believed that RSV originally took up the chicken proto-oncogene SRC (Gene ID 396442; UniProt P00523) and incorporated into its genome in the mutated concogene form. c-Src contains six functional regions, Src homology 4 (SH4) domain, unique region, SH3 domain, SH2 domain, catalytic domain, and short regulatory tail. In its inactive state, Src is phosphorylated at Tyr527. The pTyr527 interacts with the SH2 domain which helps the SH3 domain interact with the linker domain and consequently keeps the inactive unit tightly bound. Dephosphorylation of pTyr527 destabilizes the inactive conformation, opening up the SH3, SH2 and the kinase domains, leading to Tyr416 autophosphorylation and c-Src activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Src
Applications Immunocytochemistry
Classification Monoclonal
Clone GD11
Conjugate Alexa Fluor 488
Formulation Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Accession No. P00526
Gene Symbols V-SRC; SRC
Host Species Mouse
Immunogen Recombinant PrA-RSV p60src.
Purification Method Protein G Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Cell Structure
Primary or Secondary Primary
Gene ID (Entrez) P00526.3
Target Species Avian, Human, Mink, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1
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For Research Use Only

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