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STX1A, Mouse, Clone: SP8, Abnova™

Catalog No. 89113464 Shop All Abnova Corporation Products
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89-113-464 100 μL
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Catalog No. 89-113-464 Supplier Abnova Corporation Supplier No. MAB8435
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Description

Mouse monoclonal antibody raised against native STX1A.

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM

Specifications

Antigen STX1A
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone SP8
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against native STX1A.
Dilution Western Blot (1:1000) Immunohistochemistry (1:1000) The optimal working dilution should be determined by the end user.
Formulation In 10mM HEPES, 150mM NaCl, pH 7.5 (50% glycerol, 0.1mg/mL BSA)
Gene STX1A
Gene Alias HPC-1/STX1/p35-1
Gene Symbols STX1A
Host Species Mouse
Immunogen Native purified human brain STX1A.
Purification Method Protein G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6804
Test Specificity This antibody has been directly tested for reactivity in human, rat, pig, and hamster. This antibody is specific to the ∼ 36 KDa syntaxin protein in Western blots of rat brain lysate. This antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections.
Target Species Hamster, Human, Pig, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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