Learn More
Description
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq
Specifications
Specifications
| Antigen | TBK1 |
| Applications | Western Blot |
| Classification | Monoclonal |
| Clone | 108A429 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against synthetic peptide of TBK1. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.05% BSA, 0.05% sodium azide) |
| Gene | TBK1 |
| Gene Alias | FLJ11330/NAK/T2K |
| Show More |
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.