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Description
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq
Specifications
Specifications
| Antigen | TCEB2 |
| Applications | ELISA, Western Blot |
| Classification | Monoclonal |
| Clone | 9y74 |
| Concentration | 1 ug/uL |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against full length recombinant TCEB2. |
| Dilution | Western Blot (1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | In citrate-Tris-HCl, pH 7.0 (0.02% Proclin 300) |
| Gene | TCEB2 |
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