MilliporeSigma™ Mouse anti-TCL1A, Clone: TCL1A, Alexa Fluor 488,

Catalog No.	Quantity	Conjugate
MABF1214AF4	100 μL	Alexa Fluor 488

Catalog No. MABF1214AF4 Supplier MilliporeSigma™ Supplier No. MABF1214AF488

Description

Mouse Monoclonal Antibody

Specifically detects TCL1A clone: TCL1A in Human samples, and it is validated for Immunocytochemistry

T-cell leukemia/lymphoma protein 1A (UniProt P56279; also known as Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, T-cell lymphoma-1) is encoded by the TCL1A (also known as TCL1) gene (Gene ID 8115) in human. TCL1A belongs to the T-cell leukemia/lymphoma 1 (TCL1) family of oncoproteins that enhance cell proliferation and survival by augmenting AKT signal transduction. TCL1A and the related TCL1B play key roles in several B and T cell malignancies. TCL1A does not exhibit enzymatic activity and functions as an AKT activity enhancer via binding to its pleckstrin homology (PH) domain, resulting in enhanced phosphorylation of downstream AKT substrates, such as glycogen synthase kinase-3 beta (GSK3beta). TCL1A is also reported to interact with IkappaB, albeit as a ∼100-fold lower affinity than NF-kappaB.

Specifications

• Antigen: TCL1A
• Applications: Immunocytochemistry
• Classification: Monoclonal
• Clone: TCL1A
• Conjugate: Alexa Fluor 488
• Formulation: Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
• Gene Accession No.: P56279
• Gene Symbols: TCL1A; TCL1
• Host Species: Mouse
• Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 60-73 (RPMTPTQIGPSLLP) of human TCL1A.
• Purification Method: Protein G Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Inflammation and Immunology
• Primary or Secondary: Primary
• Gene ID (Entrez): NM_021966
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG

For Research Use Only