Terminal Transferase (TdT) Mouse anti-Human, Brilliant Violet 421, Clone: E17-1519, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 565230
The E17-1519 monoclonal antibody specifically recognizes Terminal deoxynucleotidyl transferase (TdT), which is also known as Terminal transferase, or DNA nucleotidylexotransferase (DNTT). TdT is a 60 kDa nuclear polymerase that catalyzes the template-independent addition of deoxynucleotides to the 3'-hydroxyl termini of single-stranded oligonucleotide primer segments. TdT can contribute to antigen receptor diversity by N region diversification of rearranging immunoglobulin heavy chain and T cell receptor gene segments during pre-B and pre-T cell development. It is also expressed by certain lymphomas and leukemias.
The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
|Terminal Transferase (TdT)|
|TdT; DNTT; Terminal transferase; Terminal addition enzyme|
|Purified Human TdT|
|Flow Cytometry, Immunocytochemistry|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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