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Description
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq
Specifications
Specifications
| Antigen | THBD |
| Applications | Immunohistochemistry, Immunohistochemistry (Frozen) |
| Classification | Monoclonal |
| Clone | 15C8 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant THBD. |
| Dilution | Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user. |
| Formulation | Lyophilized from tissue culture supernatant (0.09% sodium azide) |
| Gene | THBD |
| Gene Alias | CD141/THRM/TM |
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