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TIGIT Mouse anti-Mouse, APC-R700, Clone: 1G9, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 565474
Description
The 1G9 monoclonal antibody specifically binds to T cell immunoreceptor with Ig and ITIM domains (TIGIT) which is also known as, V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT is a 26 kDa, type I transmembrane glycoprotein that belongs to the poliovirus receptor (PVR) family. TIGIT is expressed on activated and memory CD4+ T cells and CD8+ T cells, follicular T helper cells, regulatory T cells, and NK cells. Its ligands include the poliovirus receptor (PVR, aka, CD155), poliovirus receptor-related protein 2 (PVRL2, aka, CD112), and poliovirus receptor-related protein 3 (PVRL3, CD113). TIGIT functions as a negative regulator of T cell and NK cell responses including proliferation, cytotoxicity, and the production of proinflammatory cytokines. TIGIT-deficient mice are reportedly more susceptible to developing autoimmune diseases in certain model systems.
This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

Specifications
TIGIT | |
Monoclonal | |
0.2mg/mL | |
Tigit; Vstm3; T cell immunoreceptor with Ig and ITIM domains | |
Mouse | |
Affinity Purified | |
RUO | |
Mouse | |
IgG1 κ |
Flow Cytometry | |
1G9 | |
APC-R700 | |
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide. | |
Mouse TIGIT Recombinant Protein | |
50 μg | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Safety and Handling
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