TLR3, Mouse, Clone: 40C1285, Abnova™

Catalog No.	Quantity
89-111-548	100 μg

Catalog No. 89-111-548 Supplier Abnova Corporation Supplier No. MAB3706

Description

Mouse monoclonal antibody raised against synthetic peptide of TLR3.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq

Specifications

• Antigen: TLR3
• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 40C1285
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against synthetic peptide of TLR3.
• Dilution: Immunoprecipitation (2 ug/10⁶ cells) Western Blot (1-3 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: TLR3
• Gene Alias: CD283
• Gene Symbols: TLR3
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to cytoplasmic portion of human TLR3.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7098
• Test Specificity: Recognizes human Toll-like Receptor 3 (TLR3).
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1