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TLR4, Mouse, Clone: 1H7, Abnova™

Catalog No. 89105624 Shop All Abnova Corporation Products
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200 μL
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89-105-624 200 μL
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Catalog No. 89-105-624 Supplier Abnova Corporation Supplier No. H00007099M03A
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Description

Mouse monoclonal antibody raised against a partial recombinant TLR4.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq

Sequence: PMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLA

Specifications

Antigen TLR4
Applications ELISA
Classification Monoclonal
Clone 1H7
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a partial recombinant TLR4.
Formulation ascites with no preservative
Gene TLR4
Gene Accession No. NM_138554
Gene Alias ARMD10/CD284/TOLL/hToll
Gene Symbols TLR4
Host Species Mouse
Immunogen TLR4 (NP_612564,214 a.a. ∽ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7099
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Ascites
Isotype IgG2a κ
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