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MilliporeSigma™ Mouse anti-TNFα Receptor, Clone: 13F9.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC615

Catalog No. MABC615MI


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Description

Description

Specifically detects TNFα Receptor clone: 13F9.1 in Human, Mouse samples, and it is validated for Immunohistochemistry, Western Blotting

Tumor necrosis factor receptor superfamily member 1A (UniProt P19438; also known as CD120a, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor-alpha receptor, Tumor necrosis factor receptor type 1) is encoded by the TNFRSF1A (also known as FPF, MS5, TNFAR, TNFAR55, TNFAR60, TNFR1) gene (Gene ID 7132) in human. It functions as a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. Upon activation, TNFalpha receptor mediates apoptotic, anti-viral, and other cellular signaling events. Binding of TNF-alpha to the extracellular domain of TNF receptor leads to homotrimerization. Proteolytic cleavage results in the relese of Tumor necrosis factor-binding protein 1 (TBP1). Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TNFα Receptor
Monoclonal
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
TNFRSF1A; TNFAR; TNFR1
GST-tagged recombinant protein corresponding to the extracellular domain of human TNFα Receptor.
100 μg
Apoptosis, Cancer
NP_001056
Stable for one year at 2°C to 8°C from date of receipt.
IgG1 κ
Immunohistochemistry, Western Blot
13F9.1
P19438
Mouse
Protein G Purified
RUO
Primary
Human, Mouse
Purified
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