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MilliporeSigma™ Mouse anti-TNFα Receptor, Clone: 13F9.1,

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MABC615MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects TNFα Receptor clone: 13F9.1 in Human, Mouse samples, and it is validated for Immunohistochemistry, Western Blotting

Tumor necrosis factor receptor superfamily member 1A (UniProt P19438; also known as CD120a, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor-alpha receptor, Tumor necrosis factor receptor type 1) is encoded by the TNFRSF1A (also known as FPF, MS5, TNFAR, TNFAR55, TNFAR60, TNFR1) gene (Gene ID 7132) in human. It functions as a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. Upon activation, TNFalpha receptor mediates apoptotic, anti-viral, and other cellular signaling events. Binding of TNF-alpha to the extracellular domain of TNF receptor leads to homotrimerization. Proteolytic cleavage results in the relese of Tumor necrosis factor-binding protein 1 (TBP1). Defects in TNF receptor cause tumor necrosis factor receptor-associated periodic syndrome (TRAPS), a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNFα Receptor
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 13F9.1
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P19438
Gene Symbols TNFRSF1A; TNFAR; TNFR1
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the extracellular domain of human TNFα Receptor.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001056
Target Species Human, Mouse
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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