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Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq]
Specifications
Specifications
| Antigen | TNFRSF4 |
| Applications | Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation |
| Classification | Monoclonal |
| Clone | Ber Act 35 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against native TNFRSF4. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In 50mM sodium phosphate buffer, 100mM potassium chloride, 150mM NaCl, pH 7.5 (0.5mg/mL gentamicin sulfate) |
| Gene | TNFRSF4 |
| Gene Alias | ACT35/CD134/OX40/TXGP1L |
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