TNNI1, Mouse, Clone: 7G2, Abnova™

Mouse monoclonal antibody raised against full-length native TNNI1.

Supplier:  Abnova Corporation MAB7323

Catalog No. 89-113-167

Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq

Specifications

• Antigen: TNNI1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: TNNI1
• Gene Symbols: TNNI1
• Immunogen: Native purified human TNNI1.
• Regulatory Status: RUO
• Gene ID (Entrez): 7135
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 7G2
• Description: Mouse monoclonal antibody raised against full length native TNNI1.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: DKFZp451O223/SSTNI/TNN1
• Host Species: Mouse
• Quantity: 200 μg
• Primary or Secondary: Primary
• Test Specificity: Troponin I from human skeletal muscle.Cross-reaction of this with cardiac troponin I is less then 1.5%.
• Content And Storage: Store at 4°C. Do not freeze.
• Isotype: IgG2b