TRAF2, Mouse, Clone: 33A1293, Abnova™

Catalog No.	Quantity
89-107-832	100 μg

Catalog No. 89-107-832 Supplier Abnova Corporation Supplier No. MAB0061

Description

Mouse monoclonal antibody raised against partial recombinant TRAF2.

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq

Specifications

• Antigen: TRAF2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 33A1293
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant TRAF2.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% BSA, 0.05% sodium azide)
• Gene: TRAF2
• Gene Alias: MGC:45012/TRAP/TRAP3
• Gene Symbols: TRAF2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 205-222 of human TRAF2.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7186
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG