Transglutaminase 2/TGM2 Antibody (TGM2/419), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP24459400	Novus Biologicals NBP2445940.02MG	0.02 mg
NBP24459401	Novus Biologicals NBP2445940.1MG	0.1 mg
NBP24459402	Novus Biologicals NBP2445940.2MG	0.2 mg

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Transglutaminase 2/TGM2 Monoclonal specifically detects Transglutaminase 2/TGM2 in Human, Mouse, Rat, Monkey, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Transglutaminase 2/TGM2
• Concentration: 0.2mg/mL
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Apoptosis, Immune System Diseases, Immunology, Signal Transduction
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
• Gene Symbols: TGM2
• Isotype: IgG2a κ
• Purification Method: Protein A or G purified
• Test Specificity: Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

• Clone: TGM2/419
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse, Rat, Monkey, Rabbit
• Gene Accession No.: P21980
• Gene ID (Entrez): 7052
• Immunogen: Recombinant full-length human TGM2 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

For Research Use Only