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TYMS, Mouse, Clone: TS 106, Abnova™

Catalog No. 89111403 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-111-403 100 μg
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Catalog No. 89-111-403 Supplier Abnova Corporation Supplier No. MAB3411

Description

Mouse monoclonal antibody raised against recombinant TYMS.

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq

Specifications

Antigen TYMS
Applications Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone TS 106
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against recombinant TYMS.
Dilution Immunoprecipitation (2 ug/mg protein lysate) Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (0.09% sodium azide)
Gene TYMS
Gene Alias HsT422/MGC88736/TMS/TS/TSase
Gene Symbols TYMS
Host Species Mouse
Immunogen Recombinant protein corresponding to human TYMS.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7298
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Form Liquid
Isotype IgG1 κ
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