XRCC5, Mouse, Clone: MEM-54, Abnova™

Mouse monoclonal antibody raised against native XRCC5.

Supplier:  Abnova Corporation MAB6468

Catalog No. 89-112-883

Description

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by nonhomologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq

Specifications

• Antigen: XRCC5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunocytochemistry (2 ug/mL) Immunofluorescence Immunoprecipitation The optimal working dilution should be determined by the end user.
• Gene: XRCC5
• Gene Symbols: XRCC5
• Immunogen: Native purified XRCC5 from human whole T-lymphocytes.
• Regulatory Status: RUO
• Gene ID (Entrez): 7520
• Target Species: Human
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation
• Clone: MEM-54
• Description: Mouse monoclonal antibody raised against native XRCC5.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: FLJ39089/KARP-1/KARP1/KU80/KUB2/Ku86/NFIV
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody reacts with Ku80, a 80 KDa subunit of Ku autoantigen (heterodimer of72 and 87 KDa polypeptides). Ku autoantigen is involved in DNA repair and in V(D) Jrecombination through its ability to bind DNA double-strand breaks.
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a