ZAP70, Mouse, HRP, Clone: SBZAP, Abnova™

Catalog No.	Quantity
89-112-522	1 mL

Catalog No. 89-112-522 Supplier Abnova Corporation Supplier No. MAB5890

Description

Mouse monoclonal antibody raised against partial recombinant ZAP70.

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: ZAP70
• Applications: ELISA, Flow Cytometry
• Classification: Monoclonal
• Clone: SBZAP
• Concentration: Lot specific
• Conjugate: HRP
• Description: Mouse monoclonal antibody raised against partial recombinant ZAP70.
• Dilution: ELISA (1:1000-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (50% glycerol)
• Gene: ZAP70
• Gene Alias: FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
• Gene Symbols: ZAP70
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 280-309 of human ZAP70.
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7535
• Test Specificity: human TCR ζ; Zap-70 (Mr 70 KDa).
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. For long term storage store at -20°C.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
  
• Form: Liquid
• Isotype: IgG1 κ