ZAP70, Mouse, PE, Clone: 1E7.2, Abnova™

Mouse monoclonal antibody raised against synthetic peptide of ZAP70.

Supplier:  Abnova Corporation MAB10158

Catalog No. 89-108-407

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: ZAP70
• Classification: Monoclonal
• Conjugate: PE
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene Alias: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography purification
• Regulatory Status: RUO
• Gene ID (Entrez): 7535
• Content And Storage: Store at 4°C. Do not freeze.
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: 1E7.2
• Description: zeta-chain (TCR) associated protein kinase 70kDa
• Gene: ZAP70
• Gene Symbols: ZAP70
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 282-307 of human ZAP70.
• Quantity: 100 Reactions
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Purified