Gibco™ Mouse CXCL4 (PF4) Recombinant Protein, PeproTech®

Description

Recombinant Protein

Recombinant Murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).

Specifications

• Accession Number: Q9Z126
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 56744
• Molecular Weight (g/mol): 8.2 kDa
• Name: Mouse CXCL4 (PF4)
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: chemokine (C-X-C motif) ligand 4; C-X-C motif chemokine 4; Cxcl4; Endothelial cell growth inhibitor; Iroplact; oncostatin-A; PF4; PF-4; Pf4a; Platelet factor 4; Platelet factor 4, short form; RATPF4A; Scyb4
• Common Name: PF4
• Gene Symbol: Pf4
• Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.