Invitrogen™ Mouse GM-CSF Recombinant Protein, eBioscience™

Description

Recombinant Protein

Description: Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a potent species-specific stimulator of bone marrow cells. GM-CSF stimulates precursor cells of granulocytes, macrophages, and eosinophils. GM-CSF is produced by a number of different cell types in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. Recombinant mouse GM-CSF is a 14.0 kDa protein containing 125 amino acid residues. Purity: >98%. Molecular Weight: 14.0 kDa.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.

Specifications

• Accession Number: P01587
• For Use With (Application): Control
• Formulation: protein with no preservative
• Gene ID (Entrez): 12981
• Molecular Weight (g/mol): 14 kDa
• Name: Mouse GM-CSF
• Quantity: 20 μg
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
• Common Name: GM-CSF
• Gene Symbol: Csf2
• Product Type: Recombinant Protein
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Mouse GM-CSF recombinant protein consists of 125 amino acids
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: >98%

Safety and Handling

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