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Invitrogen™ Mouse IL-17A, AOF Recombinant Protein

Catalog No. PIRP87768
Encompass
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Quantity:
100 μg

E. coli Recombinant Protein

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
  • Purity: >95% by SDS-Page
  • Endotoxin Concentration: AX41 ≤EUs/μg
  • Protein Length: 134 aa.
  • Biological Activity: <5 ng/mL
  • Molecular Weight: 15.1 kDa
  • Animal Origin Free: Yes
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q62386
For Use With (Application) Control, ELISA, Functional Assay, Gel Shift, Western Blot
Formulation 10 mM sodium phosphate, 150 mM sodium sulfate with no preservative
Gene ID (Entrez) 16171
Molecular Weight (g/mol) 15.1 kDa
Name Mouse IL-17 A, AOF
Quantity 100 μg
Source E. coli
Storage Requirements -20°C
Regulatory Status RUO
Gene Alias BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; IL17A; IL-17 A; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 A; interleukin 17 A-like; interleukin-17; Interleukin17A; Interleukin-17 A; LOC100339322; R-IL-17-A
Gene Symbol IL17A
Specific Reactivity Mouse
Conjugate Unconjugated
Recombinant Recombinant
Form Lyophilized
Purity or Quality Grade >95%
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