Invitrogen™ Mouse SCF, AOF Recombinant Protein

Description

E. coli Recombinant Protein

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

• Purity: >95% by SDS-Page
• Endotoxin Concentration: AX41 ≤EUs/μg
• Protein Length: 165 aa.
• Biological Activity: <20 ng/mL
• Molecular Weight: 18.4 kDa
• Animal Origin Free: Yes

Specifications

• Accession Number: P20826
• For Use With (Application): Control, ELISA, Functional Assay, Gel Shift, Western Blot
• Formulation: 20 mM sodium phosphate with no preservative
• Gene ID (Entrez): 17311
• Molecular Weight (g/mol): 18.4 kDa
• Name: Mouse Stem Cell Factor (SCF), AOF
• Quantity: 100 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Gene Alias: 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; Hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; Slf; Soluble KIT ligand; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1; stem cell factor, CSF
• Gene Symbol: Kitl
• Specific Reactivity: Mouse
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Form: Lyophilized
• Purity or Quality Grade: >95%