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Invitrogen™ Mouse TNF-alpha High Sensitivity ELISA Non-distribution product as customer accommodation.

For the quantitative detection of mouse TNF-alpha.

Manufacturer:  Invitrogen™ BMS6001TEN

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Catalog No. 50-112-8648


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-17
Biotin-Conjugate anti-mouse IL-17 monoclonal antibody
Streptavidin-HRP
Mouse IL-17 Standard lyophilized, 1ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Specifications

Specifications

Q62386
Biotin
16171
Adhesive Plate Covers
10 x 96 tests
1.6 pg/mL
50μL
Mouse
1 hr 20 min
Mouse
Interleukin-17, IL-17A, CTLA8
9.1%
7.8-500 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Serum,Supernatant
Serum,50 μL|Supernatant,50 μL
2-8°C
3 hr 10 min
Il17a
8.5%
HRP
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