Invitrogen™ Mouse TPO (Thrombopoietin), AOF Recombinant Protein

Description

E. coli Recombinant Protein

Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.

• Purity: >95% by SDS-Page
• Endotoxin Concentration: AX41 ≤EUs/μg
• Protein Length: 175 aa.
• Biological Activity: <5 ng/mL
• Molecular Weight: 18.7 kDa
• Animal Origin Free: Yes

Specifications

• Accession Number: P40226
• For Use With (Application): Control, ELISA, Functional Assay, Gel Shift, Western Blot
• Formulation: 10 mM sodium phosphate with no preservative
• Gene ID (Entrez): 21832
• Molecular Weight (g/mol): 18.7 kDa
• Name: Mouse Thrombopoietin (TPO), AOF
• Quantity: 100 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Gene Alias: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGDF; MKCSF; ML; MPL ligand; Mpllg; Myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; THCYT1; THPO; Thrombopoietin; TPO
• Gene Symbol: THPO
• Specific Reactivity: Mouse
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Form: Lyophilized
• Purity or Quality Grade: >95%