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Invitrogen™ MOV10 Polyclonal Antibody
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Catalog No. PIPA565103
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100 μL
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PIPA565103 100 μL
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Catalog No. PIPA565103 Supplier Invitrogen™ Supplier No. PA565103
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LEELQMEHDIR HYDLESVPMT WDPVDQNPRL LTLEVPGVTE SRPSVLRGDH LFALLSSETH QEDPITYKGF VHKVELDRVK LSFSMSLLSR FVDGLTFKVN FTFNRQPLRV QHRALELTGR WLLWPMLFPV AP Highest antigen sequence identity to the following orthologs - mouse 94%, rat 95%.

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MOV10
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MOV10
Gene Accession No. Q9HCE1
Gene Alias Armitage homolog; C77703; capping protein (actin filament) muscle Z-line, alpha 1; Capza1; fSAP113; functional spliceosome-associated protein 113; gb110; Helicase MOV-10; KIAA1631; Moloney leukemia virus 10; moloney leukemia virus 10 protein; Mov10; Mov-10; Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10; Mov10, Moloney leukemia virus 10, homolog; putative helicase MOV-10
Gene Symbols MOV10
Host Species Rabbit
Immunogen Recombinant Human MOV10. Recombinant protein control fragment (Product #RP-105859).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4343
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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