Invitrogen™ MOV10 Recombinant Rabbit Monoclonal Antibody (1M7M9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538166

Catalog No. PIMA538166

Description

Positive Samples: U2OS, HepG2, NIH/3T3, U-87MG, Mouse liver, Rat kidney Immunogen sequence: AATVTSYLKL LLAPSSKKGK ARLSPRSVGV ISPYRKQVEK IRYCITKLDR ELRGLDDIKD LKVGSVEEFQ GQERSVILIS TVRSSQSFVQ LDLDFNLGFL K.

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt].

Specifications

• Antigen: MOV10
• Classification: Recombinant Monoclonal
• Concentration: 2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P23249, Q9HCE1
• Gene Symbols: MOV10
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800-900 of human MOV10 (Q9HCE1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 1M7M9
• Conjugate: Unconjugated
• Gene: MOV10
• Gene Alias: Armitage homolog; C77703; capping protein (actin filament) muscle Z-line, alpha 1; Capza1; fSAP113; functional spliceosome-associated protein 113; gb110; Helicase MOV-10; KIAA1631; Moloney leukemia virus 10; moloney leukemia virus 10 protein; Mov10; Mov-10; Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10; Mov10, Moloney leukemia virus 10, homolog; putative helicase MOV-10
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17454, 310756, 4343
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid