Invitrogen™ MOV10L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106711

Catalog No. PIPA5106711

Description

Antibody detects endogenous levels of total MOV10L1.

Isoform 1: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). {ECO:0000269; PubMed:20534472, ECO:0000269; PubMed:20547853, ECO:0000269; PubMed:23166510, ECO:0000269; PubMed:25762440}.; Isoform 2: May act downstream of MEF2C during heart formation. Acts as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, suggesting that it may suppress these processes through the regulation of CDKN1A. Such results however require additional evidence. {ECO:0000305; PubMed:11854500}.

Specifications

• Antigen: MOV10L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MOV10L1
• Gene Alias: Cardiac helicase activated by MEF2 protein; cardiac helicase activated by MEF2C protein; cardiac-specific RNA helicase; Champ; Csm; DJ402G11.8; Moloney leukemia virus 10-like 1; moloney leukemia virus 10-like protein 1; Moloney leukemia virus 10-like protein 1 homolog; Mov10 RISC complex RNA helicase like 1; Mov10l1; Mov10l1, Moloney leukemia virus 10-like 1, homolog; Mov10-like 1; MOV10-like protein 1; MOV10-like protein 1 homolog; putative helicase Mov10l1; RNA helicase Mov10l1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 300141, 54456, 83456
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99MV5, Q9BXT6
• Gene Symbols: MOV10L1
• Immunogen: A synthesized peptide derived from human MOV10L1(Accession Q9BXT6), corresponding to amino acid residues Q317-L367.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov