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Invitrogen™ MPEG1 Polyclonal Antibody
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Catalog No. PIPA531958
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100 μL
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PIPA531958 100 μL
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Catalog No. PIPA531958 Supplier Invitrogen™ Supplier No. PA531958
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: THP-1. Predicted reactivity: Pig (81%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The MPEG1 (Macrophage Expressed Gene 1) gene encodes a protein known as Perforin-2, which is part of the immune system and plays a crucial role in host defense mechanisms. Located on chromosome 11, MPEG1/Perforin-2 is primarily expressed in macrophages, dendritic cells, and other immune cells. The protein functions by forming pores in the membranes of pathogenic bacteria, leading to their lysis and destruction. This pore-forming capability is integral to the innate immune response, providing a rapid means to target and eliminate intracellular pathogens. MPEG1's activity contributes significantly to the antimicrobial arsenal of the innate immune system, and deficiencies in this protein can lead to increased susceptibility to infections. Ongoing research is focused on understanding how MPEG1/Perforin-2 can be leveraged or augmented to enhance immune responses and potential therapeutic applications in infectious disease and immunotherapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MPEG1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Mpeg1
Gene Accession No. Q2M385
Gene Alias macrophage expressed 1; macrophage expressed gene 1; macrophage gene 1 protein; Macrophage-expressed gene 1 protein; MGC150002; MGC150003; MPEG1; MPG1; Mpg-1; MPS1; P-2; perforin 2; Perforin-2; Protein MPS1
Gene Symbols Mpeg1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human MPEG1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 219972
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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