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MilliporeSigma™ MPK-3 (DUSP6), Mouse, Unlabeled, Clone: 5H6.1,

Catalog No. MABS1726 Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABS1726 100 μg Unconjugated
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Catalog No. MABS1726 Supplier MilliporeSigma™ Supplier No. MABS1726
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Description

Mouse Monoclonal Antibody

Dual specificity protein phosphatase 6 (EC 3.1.3.16; EC 3.1.3.48; UniProt Q16828; also known as Dual specificity protein phosphatase PYST1, MAP kinase phosphatase 3, Mitogen-activated protein kinase phosphatase 3, MKP-3) is encoded by the DUSP6 (also known as HH19, MKP3, PYST1) gene (Gene ID 1848) in human. MPK-3 (DUSP6) belongs to the family of dual-specificity phosphatases (DUSPs) that mediate dephosphorylation of MAPKs on threonine/serine and tyrosine residues. DUSP6 is upregulated in HER2+ carcinomas and is among several DUSPs thought to be involved in breast cancer metastasis. DUSP1, DUSP4, and DUSP6 are induced during epithelial-to-mesenchymal transition (EMT) and are involved in forming and maintaining breast cancer stem cells (CSCs), DUSP1 knockdown reduces CSC formation, while DUSP4 or DUSP6 knockdown enhances CSC formation. PKC CK2alpha is reported to phosphorylate DUSP6 and increase its dephosphatase activity. ERK1/2, on the other hand, can phosphorylate DUSP6 to promote its proteosomal degradation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MPK-3 (DUSP6)
Applications Western Blot
Classification Monoclonal
Clone 5H6.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene DUSP6, HH19, MKP3, PYST1
Gene Accession No. Q16828
Host Species Mouse
Immunogen GST-tagged recombinant human MPK-3 (DUSP6) rhodanese domain fragment.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_001937
Test Specificity Clone 5H6.1 targets an epitope within the rhodanese domain present in both spliced isoforms of human MPK-3 (DUSP6) reported by UniProt (Q16828).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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