Invitrogen™ MPP10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587589

Catalog No. PIPA587589

Description

Immunogen sequence: RIRDQAWDDV VRKEKPKEDA YEYKKRLTLD HEKSKLSLAE IYEQEYIKLN QQKTAEEENP EHVEIQKMMD SLFLKLDALS NFHFIPKPPV PEIKVVSNLP AITMEEVAPV SVSDAALLAP EEIKEKNKAG DIKTAAEKTA TDKKRERRKK KYQKRMKIKE KEKRRKLLEK SSVDQAGKYS KTVASEKLKQ LTKTGKASFI KDEGKDKALK SSQAFFSKLQ DQVKMQINDA KKTEKKKKKR QDISVHKLKL; Positive Samples: MCF-7, HeLa; Cellular Location: Chromosome, Nucleus, nucleolus.

MPP10 (M-phase phosphoprotein 10), also known as MPHOSPH10, is a 681 amino acid protein that localizes to the fibrillar region of the nucleolus. Phosphorylated in the M (mitotic) phase of the cell cycle, MPP10 is a component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex and is required for the early cleavages during pre-18S ribosomal RNA processing. MPP10 forms a heterotrimeric complex with IMP-3 and IMP-4, which may be required for its association with nucleolar components. The gene encoding MPP10 is localized to human chromosome 2, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

Specifications

• Antigen: MPP10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MPHOSPH10
• Gene Alias: 2810453H10Rik; 5730405D16Rik; AI326008; CT90; M phase phosphoprotein 10; M-phase phosphoprotein 10; M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Mphosph10; MPP10; MPP10P; PPP1R106; protein phosphatase 1, regulatory subunit 106; U3 small nucleolar ribonucleoprotein; U3 small nucleolar ribonucleoprotein protein MPP10
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10199, 67973
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00566, Q810V0
• Gene Symbols: MPHOSPH10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 432-681 of human MPHOSPH10 (NP_0057821).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG