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Invitrogen™ MPP8 Polyclonal Antibody
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Catalog No. PIPA558891
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PIPA558891 100 μL
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Catalog No. PIPA558891 Supplier Invitrogen™ Supplier No. PA558891
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GLEHGFEKPL DSAMSAEEDT DVRGRRKKKT PRKAEDTREN RKLENKNAFL EKKTVPKKQR NQDRSKSAAE LEKLMPVSAQ TPKGRRLSGE ERGLWSTDSA EEDKETKRNE SKE Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 58%.

Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MPP8
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MPHOSPH8
Gene Accession No. Q99549
Gene Alias 1500035L22Rik; 4930548G07Rik; Ab2-008; AU040635; HSMPP8; M-phase phosphoprotein 8; M-phase phosphoprotein, mpp; M-phase phosphoprotein, mpp8; Mphosph8; MPP8; RGD1305133; TWA3; Two hybrid-associated protein 3 with RanBPM
Gene Symbols MPHOSPH8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MPP8. Recombinant protein control fragment (Product #RP-98007).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54737
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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