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MPP8 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501564135
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50-156-4135 20 μL
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Catalog No. 50-156-4135 Supplier Bethyl Laboratories, Inc Supplier No. A303051AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Heterochromatin component that specifically recognizes and binds methylated ′Lys-9′ of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).

Specifications

Antigen MPP8
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene MPHOSPH8
Gene Accession No. Q99549
Gene Alias HSMPP8, TWA3, mpp8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, two hybrid-associated protein 3 with RanBPM
Gene Symbols MPHOSPH8
Host Species Rabbit
Immunogen Between 1 and 50
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54737
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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